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Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis

The ClpP protease is found in all kingdoms of life, from bacteria to humans. In general, this protease forms a homo-oligomeric complex composed of 14 identical subunits, which associates with its cognate ATPase in a symmetrical manner. Here we show that, in contrast to this general architecture, the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nagpal, Jyotsna, Paxman, Jason J., Zammit, Jessica E., Thomas, Adam A., Truscott, Kaye N., Heras, Begoña, Dougan, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889138/
https://ncbi.nlm.nih.gov/pubmed/31792243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53736-8
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