Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts

BACKGROUND: The limited proliferative ability of hepatocytes is a major limitation to meet their demand for cell-based therapy, bio-artificial liver device, and drug tests. One strategy is to amplify cells at the hepatoblast (HB) stage. However, expansion of HBs with their bipotency preserved is cha...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Pan, Tingcai, Chen, Yan, Zhuang, Yuanqi, Yang, Fan, Xu, Yingying, Tao, Jiawang, You, Kai, Wang, Ning, Wu, Yuhang, Lin, Xianhua, Wu, Feima, Liu, Yanli, Li, Yingrui, Wang, Guodong, Li, Yin-xiong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888929/
https://ncbi.nlm.nih.gov/pubmed/31791391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1463-y
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