Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy

Abstract Background Various methods have been developed to generate hepatic cells from human pluripotent stem cells (hPSCs) that rely on the combined use of multiple expensive growth factors, limiting industrial-scale production and widespread applications. Small molecules offer an attractive altern...

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Detalhes bibliográficos
Main Authors: Tingcai Pan, Ning Wang, Jiaye Zhang, Fan Yang, Yan Chen, Yuanqi Zhuang, Yingying Xu, Ji Fang, Kai You, Xianhua Lin, Yang Li, Shao Li, Kangyan Liang, Yin-xiong Li, Yi Gao
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Stem Cell Research & Therapy
Assuntos:
Hepatic differentiation
Small molecule
Human pluripotent stem cells
Hepatoblasts
Hepatocyte-like cells
Acesso em linha:https://doi.org/10.1186/s13287-022-02831-1
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