Defect of Interferon γ Leads to Impaired Wound Healing through Prolonged Neutrophilic Inflammatory Response and Enhanced MMP-2 Activation

Interferon (IFN)-γ is mainly secreted by CD4+ T helper 1 (Th1), natural killer (NK) and NKT cells after skin injury. Although IFN-γ is well known regarding its inhibitory effects on collagen synthesis by fibroblasts in vitro, information is limited regarding its role in wound healing in vivo. In the...

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Publié dans:Int J Mol Sci
Auteurs principaux: Kanno, Emi, Tanno, Hiromasa, Masaki, Airi, Sasaki, Ayako, Sato, Noriko, Goto, Maiko, Shisai, Mayu, Yamaguchi, Kenji, Takagi, Naoyuki, Shoji, Miki, Kitai, Yuki, Sato, Ko, Kasamatsu, Jun, Ishii, Keiko, Miyasaka, Tomomitsu, Kawakami, Kaori, Imai, Yoshimichi, Iwakura, Yoichiro, Maruyama, Ryoko, Tachi, Masahiro, Kawakami, Kazuyoshi
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888635/
https://ncbi.nlm.nih.gov/pubmed/31726690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20225657
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