Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene repression. Analysis of sequence data from 419 T-cell acute lymphoblastic leukemia (T-ALL) cases demonstrated a significant a...

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Veröffentlicht in:Blood
Hauptverfasser: Broux, Michael, Prieto, Cristina, Demeyer, Sofie, Vanden Bempt, Marlies, Alberti-Servera, Llucia, Lodewijckx, Inge, Vandepoel, Roel, Mentens, Nicole, Gielen, Olga, Jacobs, Kris, Geerdens, Ellen, Vicente, Carmen, de Bock, Charles E., Cools, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888143/
https://ncbi.nlm.nih.gov/pubmed/31492675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000015
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