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OSCP subunit of mitochondrial ATP synthase: role in regulation of enzyme function and of its transition to a pore

The permeability transition pore (PTP) is a latent, high‐conductance channel of the inner mitochondrial membrane. When activated, it plays a key role in cell death and therefore in several diseases. The investigation of the PTP took an unexpected turn after the discovery that cyclophilin D (the targ...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Giorgio, Valentina, Fogolari, Federico, Lippe, Giovanna, Bernardi, Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887684/
https://ncbi.nlm.nih.gov/pubmed/30291799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14513
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