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Dimers of mitochondrial ATP synthase form the permeability transition pore
Here we define the molecular nature of the mitochondrial permeability transition pore (PTP), a key effector of cell death. The PTP is regulated by matrix cyclophilin D (CyPD), which also binds the lateral stalk of the F(O)F(1) ATP synthase. We show that CyPD binds the oligomycin sensitivity-conferri...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625323/ https://ncbi.nlm.nih.gov/pubmed/23530243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217823110 |
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