Dimers of mitochondrial ATP synthase form the permeability transition pore

Here we define the molecular nature of the mitochondrial permeability transition pore (PTP), a key effector of cell death. The PTP is regulated by matrix cyclophilin D (CyPD), which also binds the lateral stalk of the F(O)F(1) ATP synthase. We show that CyPD binds the oligomycin sensitivity-conferri...

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Bibliografiske detaljer
Main Authors: Giorgio, Valentina, von Stockum, Sophia, Antoniel, Manuela, Fabbro, Astrid, Fogolari, Federico, Forte, Michael, Glick, Gary D., Petronilli, Valeria, Zoratti, Mario, Szabó, Ildikó, Lippe, Giovanna, Bernardi, Paolo
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625323/
https://ncbi.nlm.nih.gov/pubmed/23530243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217823110
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