The unique histidine in OSCP subunit of F‐ATP synthase mediates inhibition of the permeability transition pore by acidic pH

The permeability transition pore (PTP) is a Ca(2+)‐dependent mitochondrial channel whose opening causes a permeability increase in the inner membrane to ions and solutes. The most potent inhibitors are matrix protons, with channel block at pH 6.5. Inhibition is reversible, mediated by histidyl resid...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Antoniel, Manuela, Jones, Kristen, Antonucci, Salvatore, Spolaore, Barbara, Fogolari, Federico, Petronilli, Valeria, Giorgio, Valentina, Carraro, Michela, Di Lisa, Fabio, Forte, Michael, Szabó, Ildikó, Lippe, Giovanna, Bernardi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797955/
https://ncbi.nlm.nih.gov/pubmed/29217657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744705
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