The unique histidine in OSCP subunit of F‐ATP synthase mediates inhibition of the permeability transition pore by acidic pH

The permeability transition pore (PTP) is a Ca(2+)‐dependent mitochondrial channel whose opening causes a permeability increase in the inner membrane to ions and solutes. The most potent inhibitors are matrix protons, with channel block at pH 6.5. Inhibition is reversible, mediated by histidyl resid...

詳細記述

保存先:
書誌詳細
出版年:EMBO Rep
主要な著者: Antoniel, Manuela, Jones, Kristen, Antonucci, Salvatore, Spolaore, Barbara, Fogolari, Federico, Petronilli, Valeria, Giorgio, Valentina, Carraro, Michela, Di Lisa, Fabio, Forte, Michael, Szabó, Ildikó, Lippe, Giovanna, Bernardi, Paolo
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2017
主題:
Scientific Reports
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797955/
https://ncbi.nlm.nih.gov/pubmed/29217657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744705
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