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The ion selectivity filter is not an activation gate in TRPV1-3 channels
Activation of TRPV1 channels in sensory neurons results in opening of a cation permeation pathway that triggers the sensation of pain. Opening of TRPV1 has been proposed to involve two gates that appear to prevent ion permeation in the absence of activators: the ion selectivity filter on the externa...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6887487/ https://ncbi.nlm.nih.gov/pubmed/31724952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51212 |
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