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An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

Loading of mRNA onto the ribosomal 43S pre-initiation complex (PIC) and its subsequent scanning require the removal of the secondary structure of the by RNA helicases such as eIF4A. However, the topology and mechanics of the scanning complex bound to mRNA (48S-PIC) and the influence of its solvent-s...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Díaz-López, Irene, Toribio, René, Berlanga, Juan José, Ventoso, Iván
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887119/
https://ncbi.nlm.nih.gov/pubmed/31789591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48246
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