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Impaired tau–microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations
tau is a microtubule (MT)-associated protein that promotes tubulin assembly and stabilizes MTs by binding longitudinally along the MT surface. tau can aberrantly aggregate into pathological inclusions that define Alzheimer's disease, frontotemporal dementias, and other tauopathies. A spectrum o...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6885647/ https://ncbi.nlm.nih.gov/pubmed/31653695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010178 |
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