The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53

類似資料

• p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes
  著者:: Sandoval, Jonathan E., 等
  出版事項: (2020)
• The Inherent Processivity of the Human de Novo Methyltransferase 3A (DNMT3A) Is Enhanced by DNMT3L
  著者:: Holz-Schietinger, Celeste, 等
  出版事項: (2010)
• Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation
  著者:: Holz-Schietinger, Celeste, 等
  出版事項: (2012)
• The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity
  著者:: Nguyen, Tuong-Vi, 等
  出版事項: (2019)
• Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners
  著者:: Sandoval, Jonathan E., 等
  出版事項: (2019)