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Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation

DNA methylation is a key regulator of gene expression and changes in DNA methylation occur early in tumorigenesis. Mutations in the de novo DNA methyltransferase gene, DNMT3A, frequently occur in adult acute myeloid leukemia patients with poor prognoses. Most of the mutations occur within the dimer...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Holz-Schietinger, Celeste, Matje, Doug M., Reich, Norbert O.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438927/
https://ncbi.nlm.nih.gov/pubmed/22722925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366625
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