Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole

BACKGROUND: Drug–drug interactions (DDIs) and drug–gene interactions (DGIs) pose a serious health risk that can be avoided by dose adaptation. These interactions are investigated in strictly controlled setups, quantifying the effect of one perpetrator drug or polymorphism at a time, but in real life...

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Vydáno v:Clin Pharmacokinet
Hlavní autoři: Türk, Denise, Hanke, Nina, Wolf, Sarah, Frechen, Sebastian, Eissing, Thomas, Wendl, Thomas, Schwab, Matthias, Lehr, Thorsten
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2019
Témata:
Original Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885506/
https://ncbi.nlm.nih.gov/pubmed/31129789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-019-00777-x
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