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All-trans-retinoic acid generation is an antidotal clearance pathway for all-trans-retinal in the retina

The present study was designed to analyze the metabolites of all-trans-retinal (atRal) and compare the cytotoxicity of atRal versus its derivative all-trans-retinoic acid (atRA) in human retinal pigment epithelial (RPE) cells. We confirmed that atRA was produced in normal pig neural retina and RPE....

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Détails bibliographiques
Publié dans:J Zhejiang Univ Sci B
Auteurs principaux: Xia, Qing-qing, Zhang, Ling-min, Zhou, Ying-ying, Wu, Ya-lin, Li, Jie
Format: Artigo
Langue:Inglês
Publié: Zhejiang University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885407/
https://ncbi.nlm.nih.gov/pubmed/31749343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B1900271
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