Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the design of aging studies

The systemic delivery of tamoxifen (Tam) to activate inducible CreERT2-loxP transgenic mouse systems is now widely used in neuroscience studies. This critical technological advancement allows temporal control of DNA-cre recombination, avoidance of embryonically lethal phenotypes, and minimization of...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:GeroScience
Auteurs principaux: Chucair-Elliott, Ana J., Ocanas, Sarah R., Stanford, David R., Hadad, Niran, Wronowski, Benjamin, Otalora, Laura, Stout, Michael B., Freeman, Willard M.
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2019
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885072/
https://ncbi.nlm.nih.gov/pubmed/31493147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-019-00090-2
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires