Glutamine/glutamate metabolism rewiring in reprogrammed human hepatocyte-like cells

Human dermal fibroblasts can be reprogrammed into hepatocyte-like (HEP-L) cells by the expression of a set of transcription factors. Yet, the metabolic rewiring suffered by reprogrammed fibroblasts remains largely unknown. Here we report, using stable isotope-resolved metabolic analysis in combinati...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ballester, Maria, Sentandreu, Enrique, Luongo, Giovanna, Santamaria, Ramon, Bolonio, Miguel, Alcoriza-Balaguer, Maria Isabel, Palomino-Schätzlein, Martina, Pineda-Lucena, Antonio, Castell, Jose, Lahoz, Agustin, Bort, Roque
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884617/
https://ncbi.nlm.nih.gov/pubmed/31784643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54357-x
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