Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells

BACKGROUND: Several studies have reported the direct conversion of mouse fibroblasts to hepatocyte-like cells with different degrees of maturation by expression of hepatic fate-conversion factors. METHODS: We have used a combination of lentiviral vectors expressing hepatic fate-conversion factors wi...

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Publicat a:Stem Cell Res Ther
Autors principals: Serrano, Felipe, García-Bravo, Maria, Blazquez, Marina, Torres, Josema, Castell, Jose V., Segovia, Jose C., Bort, Roque
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962402/
https://ncbi.nlm.nih.gov/pubmed/27460218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0349-5
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