Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobin production by an unknown mechanism. Here, we report that pomalidomide induced a fetal-like erythroid diffe...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Dulmovits, Brian M., Appiah-Kubi, Abena O., Papoin, Julien, Hale, John, He, Mingzhu, Al-Abed, Yousef, Didier, Sebastien, Gould, Michael, Husain-Krautter, Sehba, Singh, Sharon A., Chan, Kyle W. H., Vlachos, Adrianna, Allen, Steven L., Taylor, Naomi, Marambaud, Philippe, An, Xiuli, Gallagher, Patrick G., Mohandas, Narla, Lipton, Jeffrey M., Liu, Johnson M., Blanc, Lionel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797024/
https://ncbi.nlm.nih.gov/pubmed/26679864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-667923
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