Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobin production by an unknown mechanism. Here, we report that pomalidomide induced a fetal-like erythroid diffe...

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Udgivet i:Blood
Main Authors: Dulmovits, Brian M., Appiah-Kubi, Abena O., Papoin, Julien, Hale, John, He, Mingzhu, Al-Abed, Yousef, Didier, Sebastien, Gould, Michael, Husain-Krautter, Sehba, Singh, Sharon A., Chan, Kyle W. H., Vlachos, Adrianna, Allen, Steven L., Taylor, Naomi, Marambaud, Philippe, An, Xiuli, Gallagher, Patrick G., Mohandas, Narla, Lipton, Jeffrey M., Liu, Johnson M., Blanc, Lionel
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797024/
https://ncbi.nlm.nih.gov/pubmed/26679864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-667923
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