Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobin production by an unknown mechanism. Here, we report that pomalidomide induced a fetal-like erythroid diffe...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Dulmovits, Brian M., Appiah-Kubi, Abena O., Papoin, Julien, Hale, John, He, Mingzhu, Al-Abed, Yousef, Didier, Sebastien, Gould, Michael, Husain-Krautter, Sehba, Singh, Sharon A., Chan, Kyle W. H., Vlachos, Adrianna, Allen, Steven L., Taylor, Naomi, Marambaud, Philippe, An, Xiuli, Gallagher, Patrick G., Mohandas, Narla, Lipton, Jeffrey M., Liu, Johnson M., Blanc, Lionel
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2016
Sujets:
Red Cells, Iron, and Erythropoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797024/
https://ncbi.nlm.nih.gov/pubmed/26679864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-667923
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