Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity

BACKGROUND: Pre-clinical and clinical studies have shown that the infusion of CAR T cells with a naive-like (T(N)) and central memory (T(CM)) phenotype is associated with prolonged in vivo T cell persistence and superior anti-tumor effects. To optimize the maintenance of such populations during the...

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Bibliografske podrobnosti
izdano v:J Immunother Cancer
Main Authors: Torres Chavez, Alejandro, McKenna, Mary Kathryn, Canestrari, Emanuele, Dann, Christina T., Ramos, Carlos A., Lulla, Premal, Leen, Ann M., Vera, Juan F., Watanabe, Norihiro
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883585/
https://ncbi.nlm.nih.gov/pubmed/31779709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0804-9
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