MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma

Radiation therapy (RT) is a cornerstone of treatment in the management of head and neck squamous cell carcinomas (HNSCC), yet treatment failure and disease recurrence are common. The p38/MK2 pathway is activated in response to cellular stressors, including radiation, and promotes tumor inflammation...

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Publicat a:Oncogene
Autors principals: Berggren, Kiersten L., Cruz, Sebastian Restrepo, Hixon, Michael D, Cowan, Andrew, Keysar, Stephen B., Craig, Stephanie, James, Jacqueline, Barry, Marc, Ozbun, Michelle A., Jimeno, Antonio, McCance, Dennis J., Beswick, Ellen J., Gan, Gregory N.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883149/
https://ncbi.nlm.nih.gov/pubmed/31417185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0945-9
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