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The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
The human ATP-binding cassette transporter ABCG2 is a key to anticancer resistance and physiological detoxification. However, the molecular mechanism of substrate transport remains enigmatic. A hydrophobic di-leucine motif in the ABCG2 core separates a large intracellular cavity from a smaller upper...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6883074/ https://ncbi.nlm.nih.gov/pubmed/31780715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13302-2 |
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