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The first intracellular loop is essential for the catalytic cycle of the human ABCG2 multidrug resistance transporter
The human multidrug transporter ABCG2 is required for physiological detoxification and mediates anticancer drug resistance. Here, we identify pivotal residues in the first intracellular loop (ICL1), constituting an intrinsic part of the transmission interface. The architecture includes a triple heli...
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| Publicado no: | FEBS Lett |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7756363/ https://ncbi.nlm.nih.gov/pubmed/33169382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13994 |
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