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The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion
The human ABC transporter ABCG2 (Breast Cancer Resistance Protein, BCRP) is implicated in anticancer resistance, in detoxification across barriers and linked to gout. Here, we generate a novel atomic model of ABCG2 using the crystal structure of ABCG5/G8. Extensive mutagenesis verifies the structure...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5653816/ https://ncbi.nlm.nih.gov/pubmed/29061978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11794-w |
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