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Specificity and Efficiency of the Uracil DNA Glycosylase-Mediated Strand Cleavage Surveyed on Large Sequence Libraries

Uracil-DNA glycosylase (UDG) is a critical DNA repair enzyme that is well conserved and ubiquitous in nearly all life forms. UDG protects genomic information integrity by catalyzing the excision from DNA of uracil nucleobases resulting from misincorporation or spontaneous cytosine deamination. UDG-m...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hölz, Kathrin, Pavlic, Angelina, Lietard, Jory, Somoza, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883067/
https://ncbi.nlm.nih.gov/pubmed/31780717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54044-x
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