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Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase

To investigate the role of Arginine 276 in the conserved leucine-loop of human uracil-DNA glycosylase (UNG), the effects of six R276 amino acid substitutions (C, E, H, L, W, and Y) on nucleotide flipping and enzyme conformational change were determined using transient and steady state, fluorescence-...

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書誌詳細
主要な著者: Chen, Cheng-Yao, Mosbaugh, Dale W., Bennett, Samuel E.
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039872/
https://ncbi.nlm.nih.gov/pubmed/15970468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2005.04.019
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