Pharmacokinetics of Micafungin in Critically Ill Patients

We investigated covariates of pharmacokinetics of micafungin in critically ill patients. After application of micafungin, plasma samples were collected. Non-linear mixed effects modelling (NONMEM 7.3) was used to develop the pharmacokinetic model. Using this model, the adequacy of a fixed 100 mg dos...

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Udgivet i:Sci Rep
Main Authors: Gastine, Silke, Lanckohr, Christian, Blessou, Magalie, Horn, Dagmar, Fobker, Manfred, Bause, Daniela, Hempel, Georg, Ellger, Björn
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882900/
https://ncbi.nlm.nih.gov/pubmed/31780687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53093-6
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