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Two-tiered enforcement of high-fidelity DNA ligation
DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. To protect the integrity of the genome, DNA ligase 1 (LIG1) discriminates against DNA junctions harboring mutagenic 3′-DNA mismatches or oxidative DNA damage, but how such high-fidelit...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6882888/ https://ncbi.nlm.nih.gov/pubmed/31780661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13478-7 |
| Oznake: |
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