Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma

BACKGROUND: Euchromatic histone-lysine-N-methyltransferases 1 and 2 (EHMT1/2, aka GLP/G9A) catalyze dimethylation of histone H3 lysine 9 (H3K9me2) and have roles in epigenetic silencing of gene expression. EHMT1/2 also have direct roles in DNA repair and are implicated in chemoresistance in several...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Watson, Zachary L., Yamamoto, Tomomi M., McMellen, Alexandra, Kim, Hyunmin, Hughes, Connor J., Wheeler, Lindsay J., Post, Miriam D., Behbakht, Kian, Bitler, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882350/
https://ncbi.nlm.nih.gov/pubmed/31775874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0758-2
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