Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress

BACKGROUND: Mutations in genes associated with homologous recombination (HR) increase an individual’s risk of developing triple-negative breast cancer (TNBC). Although known for their role in repairing dsDNA breaks, HR repair elements also stabilize and restart stalled replication forks. Essential t...

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Vydáno v:Breast Cancer Res
Hlavní autoři: Pearson, Scott J., Elswood, Jessica, Barhoumi, Rola, Ming-Whitfield, Brittini, Rijnkels, Monique, Porter, Weston W.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882179/
https://ncbi.nlm.nih.gov/pubmed/31775907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1207-z
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