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A microfluidic platform for simultaneous quantification of oxygen-dependent viscosity and shear thinning in sickle cell blood

The pathology of sickle cell disease begins with the polymerization of intracellular hemoglobin under low oxygen tension, which leads to increased blood effective viscosity and vaso-occlusion. However, it has remained unclear how single-cell changes propagate up to the scale of bulk blood effective...

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Publicado en:APL Bioeng
Main Authors: Valdez, José M., Datta, Yvonne H., Higgins, John M., Wood, David K.
Formato: Artigo
Idioma:Inglês
Publicado: AIP Publishing LLC 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881198/
https://ncbi.nlm.nih.gov/pubmed/31803859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.5118212
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