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Splicing the innate immune signalling in leukaemia

Components of the spliceosome are frequently mutated in haematopoietic malignancies. Identification of mis-spliced genes promoting transformation will uncover novel targeted therapies. Now, a long isoform of IRAK4 is shown to be upregulated in a subset of acute myeloid leukaemia patients, conferring...

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Bibliographic Details
Published in:Nat Cell Biol
Main Authors: Guillamot, Maria, Aifantis, Iannis
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880928/
https://ncbi.nlm.nih.gov/pubmed/31011166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0323-4
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