Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis

We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC) activation, and ex vivo thrombus growth. However, precise m...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood Adv
Principais autores: Holly, Stephen P., Gera, Nidhi, Wang, Putianqi, Wilson, Alexander, Guan, Ziqiang, Lin, Ling, Cooley, Brian, Alfar, Hammodah R., Patil, Ruchi G., Piatt, Raymond, Leisner, Tina M., Bergmeier, Wolfgang, Majumder, Rinku, Parise, Leslie V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880913/
https://ncbi.nlm.nih.gov/pubmed/31770438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018030767
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados