Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

BACKGROUND: Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been recognized that tumor microenvironment (TME) plays key roles. We investigated if targeting CD47 with a monoclonal antibody could e...

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Bibliografiske detaljer
Udgivet i:J Hematol Oncol
Main Authors: Pan, Yu, Lu, Fengchun, Fei, Qinglin, Yu, Xingxing, Xiong, Ping, Yu, Xunbin, Dang, Yuan, Hou, Zelin, Lin, Wenji, Lin, Xianchao, Zhang, Zheyang, Pan, Minggui, Huang, Heguang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880569/
https://ncbi.nlm.nih.gov/pubmed/31771616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0822-6
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