Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

BACKGROUND: Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been recognized that tumor microenvironment (TME) plays key roles. We investigated if targeting CD47 with a monoclonal antibody could e...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Hematol Oncol
Autori principali: Pan, Yu, Lu, Fengchun, Fei, Qinglin, Yu, Xingxing, Xiong, Ping, Yu, Xunbin, Dang, Yuan, Hou, Zelin, Lin, Wenji, Lin, Xianchao, Zhang, Zheyang, Pan, Minggui, Huang, Heguang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880569/
https://ncbi.nlm.nih.gov/pubmed/31771616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0822-6
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi