Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

BACKGROUND: Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been recognized that tumor microenvironment (TME) plays key roles. We investigated if targeting CD47 with a monoclonal antibody could e...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Pan, Yu, Lu, Fengchun, Fei, Qinglin, Yu, Xingxing, Xiong, Ping, Yu, Xunbin, Dang, Yuan, Hou, Zelin, Lin, Wenji, Lin, Xianchao, Zhang, Zheyang, Pan, Minggui, Huang, Heguang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880569/
https://ncbi.nlm.nih.gov/pubmed/31771616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0822-6
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