Lrrc55 is a novel prosurvival factor in pancreatic islets

Pancreatic islets adapt to the increase in insulin demand during pregnancy by upregulating β-cell number, insulin synthesis, and secretion. These changes require prolactin receptor (PrlR) signaling, as mice with PrlR deletion are glucose intolerant with a lower β-cell mass. Prolactin also prevents β...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Makkar, Guneet, Shrivastava, Vipul, Hlavay, Brittyne, Pretorius, Marle, Kyle, Barry D., Braun, Andrew P., Lynn, Francis C., Huang, Carol
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879869/
https://ncbi.nlm.nih.gov/pubmed/31526288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00028.2019
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