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Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells
Pancreatic islets adapt to insulin resistance of pregnancy by up regulating β-cell mass and increasing insulin secretion. Previously, using a transgenic mouse with global, heterozygous deletion of prolactin receptor (Prlr(+/−)), we found Prlr signaling is important for this adaptation. However, sinc...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8121891/ https://ncbi.nlm.nih.gov/pubmed/33990661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89745-9 |
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