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Detecting Weak Signals by Combining Small P-Values in Genetic Association Studies

We approach the problem of combining top-ranking association statistics or P-values from a new perspective which leads to a remarkably simple and powerful method. Statistical methods, such as the rank truncated product (RTP), have been developed for combining top-ranking associations, and this gener...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Vsevolozhskaya, Olga A., Hu, Fengjiao, Zaykin, Dmitri V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879667/
https://ncbi.nlm.nih.gov/pubmed/31824555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.01051
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