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Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism

Hyaluronan is a critical component of articular cartilage and partially helps retain aggrecan within the extracellular matrix of this tissue. During osteoarthritis, hyaluronan and aggrecan loss are an early sign of tissue damage. However, our recent attempts to mimic hyaluronan loss with the hyaluro...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Terabe, Kenya, Ohashi, Yoshifumi, Tsuchiya, Saho, Ishizuka, Shinya, Knudson, Cheryl B., Knudson, Warren
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879347/
https://ncbi.nlm.nih.gov/pubmed/31619518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009556
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