Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis

Metabolic dysfunction in chondrocytes drives the pro-catabolic phenotype associated with osteoarthritic cartilage. In this study, substitution of galactose for glucose in culture media was used to promote a renewed dependence on mitochondrial respiration and oxidative phosphorylation. Galactose repl...

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Опубликовано в: :Sci Rep
Главные авторы: Ohashi, Yoshifumi, Takahashi, Nobunori, Terabe, Kenya, Tsuchiya, Saho, Kojima, Toshihisa, Knudson, Cheryl B., Knudson, Warren, Imagama, Shiro
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302637/
https://ncbi.nlm.nih.gov/pubmed/34302034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94611-9
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