Suppression of murine osteoarthritis by 4-methylumbelliferone

Using in vitro models, we previously reported that 4-methylumbelliferone (4-MU) blocked many of the pro-catabolic features of activated chondrocytes. 4-MU also blocked safranin O loss from human cartilage explants exposed to IL1β in vitro. However, the mechanism for this chondroprotective effect was...

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Bibliografiska uppgifter
I publikationen:J Orthop Res
Huvudupphovsmän: Tsuchiya, Saho, Ohashi, Yoshifumi, Ishizuka, Shinya, Ishiguro, Naoki, O’Rourke, Dorcas P., Knudson, Cheryl B., Knudson, Warren
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162708/
https://ncbi.nlm.nih.gov/pubmed/31774188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.24541
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