The dimeric ectodomain of the alkali-sensing insulin receptor–related receptor (ectoIRR) has a droplike shape

Insulin receptor–related receptor (IRR) is a receptor tyrosine kinase of the insulin receptor family and functions as an extracellular alkali sensor that controls metabolic alkalosis in the regulation of the acid–base balance. In the present work, we sought to analyze structural features of IRR by c...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shtykova, Eleonora V., Petoukhov, Maxim V., Mozhaev, Andrey A., Deyev, Igor E., Dadinova, Liubov A., Loshkarev, Nikita A., Goryashchenko, Alexander S., Bocharov, Eduard V., Jeffries, Cy M., Svergun, Dmitri I., Batishchev, Oleg V., Petrenko, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879334/
https://ncbi.nlm.nih.gov/pubmed/31615897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010390
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