The dimeric ectodomain of the alkali-sensing insulin receptor–related receptor (ectoIRR) has a droplike shape

Insulin receptor–related receptor (IRR) is a receptor tyrosine kinase of the insulin receptor family and functions as an extracellular alkali sensor that controls metabolic alkalosis in the regulation of the acid–base balance. In the present work, we sought to analyze structural features of IRR by c...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Shtykova, Eleonora V., Petoukhov, Maxim V., Mozhaev, Andrey A., Deyev, Igor E., Dadinova, Liubov A., Loshkarev, Nikita A., Goryashchenko, Alexander S., Bocharov, Eduard V., Jeffries, Cy M., Svergun, Dmitri I., Batishchev, Oleg V., Petrenko, Alexander G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879334/
https://ncbi.nlm.nih.gov/pubmed/31615897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010390
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