Amphotericin B Penetrates into the Central Nervous System through Focal Disruption of the Blood-Brain Barrier in Experimental Hematogenous Candida Meningoencephalitis

Hematogenous Candida meningoencephalitis (HCME) is a life-threatening complication of neonates and immunocompromised children. Amphotericin B (AmB) shows poor permeation and low cerebrospinal fluid (CSF) concentrations but is effective in the treatment of HCME. In order to better understand the mech...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Petraitis, Vidmantas, Petraitiene, Ruta, Valdez, Jessica M., Pyrgos, Vasilios, Lizak, Martin J., Klaunberg, Brenda A., Kalasauskas, Darius, Basevicius, Algidas, Bacher, John D., Benjamin, Daniel K., Hope, William W., Walsh, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879260/
https://ncbi.nlm.nih.gov/pubmed/31591128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01626-19
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