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MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage. Through interacting...
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| Veröffentlicht in: | Mol Cancer |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6878665/ https://ncbi.nlm.nih.gov/pubmed/31767017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-019-1100-5 |
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