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MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage. Through interacting...
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| Publicat a: | Mol Cancer |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6878665/ https://ncbi.nlm.nih.gov/pubmed/31767017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-019-1100-5 |
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