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Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro

Activation of cannabinoid CB(1) receptors suppresses pathological pain but also produces unwanted side effects, including tolerance and physical dependence. Inhibition of fatty-acid amide hydrolase (FAAH), the major enzyme catalyzing the degradation of anandamide (AEA), an endocannabinoid, and other...

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Detalhes bibliográficos
Publicado no:Pharmacol Res
Main Authors: Slivicki, Richard A., Xu, Zhili, Mali, Sonali S., Hohmann, Andrea G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6878658/
https://ncbi.nlm.nih.gov/pubmed/30739035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2019.02.002
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