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The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response
The PI3K pathway is integral for the germinal center (GC) response. However, the contribution of protein kinase B (AKT) as a PI3K effector in GC B cells remains unknown. Here, we show that mice lacking the AKT1 and AKT2 isoforms in B cells failed to form GCs, which undermined affinity maturation and...
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| Publicado no: | Life Sci Alliance |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Life Science Alliance LLC
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6878223/ https://ncbi.nlm.nih.gov/pubmed/31767615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900506 |
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